Influenza
Influenza in itself is not one of the worst 10 diseases ever, you could miss out on work for about a week, but every 20 to 40 years it transforms itself and a pandemic occurs which means instead of tens of thousands of deaths it becomes millions. Although vaccines can be made to help prevent symptoms of flu, the disease can change so quickly the vaccines are deemed out of date; therefore it really is no surprise that a pandemic could occur.